Do short-term tests predict rodent carcinogenicity?

Do short-term tests predict rodent carcinogenicity?

Predicting carcinogenicity by using batteries of dependent short-term tests.

Among the various methods for predicting carcinogenicity from a battery of short-term tests (STTs), the carcinogenicity prediction and battery selection (CPBS) procedure is the most prominent. A major assumption of CPBS is that the STTs used in the prediction are conditionally independent. Results of recent National Toxicology Program studies of four commonly used in vitro STTs contradict this ...

Relevance of short-term carcinogenicity tests to the study of the carcinogenic potential of urban air.

It is now accepted that screening for carcinogens in animals is expensive and demonstrates carcinogenic potential rather than actual carcinogenicity in man. A number of short-term tests which depend on mutagenicity, stimulation of DNA repair, ability to produce chromosome damage or other actions, and which correlate at least to some extent with carcinogenic potential, have been devised. These h...

Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action

BACKGROUND Despite an overall decrease in incidence of and mortality from cancer, about 40% of Americans will be diagnosed with the disease in their lifetime, and around 20% will die of it. Current approaches to test carcinogenic chemicals adopt the 2-year rodent bioassay, which is costly and time-consuming. As a result, fewer than 2% of the chemicals on the market have actually been tested. Ho...

Biological Tests for Carcinogenicity

in which ground glass connections could not be used because of the large size of the flasks, it was found that benzene extracts of rubber stoppers previously washed with ether and methanol still contained blue-green fluorescing substances. These extracts had the ultraviolet absorption spectra of carcinogenic hydrocarbons and other compounds of interest. This discovery seemed of such great possi...